has function has role vaccinated in route immunizes against disease immunizes recipient cancer Homo sapiens intramuscular route recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role therapeutic cancer vaccine HPV E6/E7-encoding semliki forest virus vaccine Vvax001 6369 Jie Zheng cancer vaccine Hayleigh Kahn VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6369 Gene name: E7 Gene name: E6 1489078 A cancer vaccine consisting of a recombinant, attenuated, replication-incompetent form of the Semliki Forest Virus (SFV) vector encoding the viral oncoproteins E6 and E7 derived from the human papillomavirus (HPV), with potential immunomodulating and antineoplastic activities. The vaccine induces expression of the E6/E7 proteins and stimulates both the innate and the adaptive immune system, resulting in a potent cytotoxic T-lymphocyte (CTL) response against and lysis of tumor cells expressing HPV E6 and E7. The vaccine may help to treat patients with a history of (pre) malignant cervical lesions. 1489079 NCI: https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C148539 NCT: https://clinicaltrials.gov/study/NCT03141463