has function has role vaccinated in route immunizes against disease immunizes recipient prostate cancer Homo sapiens recombinant vector vaccine therapeutic vaccine function vaccine in clinical trial role recombinant vector vaccine role intradermal route prostate cancer vaccine therapeutic cancer vaccine hyperacute-prostate cancer vaccine Jie Zheng Gene name: Ggta1 A cancer vaccine composed of irradiated allogeneic prostate cancer cell lines (HAP-1 and HAP-2) that have been transduced with a recombinant Moloney murine leukemia virus (MoMLV)-based retroviral vector expressing the murine alpha (1,3) GT gene, a mouse gene that causes the production of a foreign pattern of protein-sugars on the cell surface. It is hoped that the immune response to the foreign substance will stimulate the immune system to attack the patient's own cancer cells that have similar proteins without this sugar pattern, causing the tumor to remain stable or shrink.. The expression of the murine alpha (1,3) galactosyltransferase [alpha (1,3) GT] gene results in the cell surface expression of alpha (1,3) galactosyl-epitopes (alpha-gal) on membrane glycoproteins and glycolipids. Hayleigh Kahn NCT: https://clinicaltrials.gov/study/NCT00105053 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6299 cancer vaccine 6299 14594