has function has role vaccinated in route immunizes against disease immunizes recipient cancer Homo sapiens intramuscular route therapeutic vaccine function peptide vaccine vaccine in clinical trial role peptide vaccine role therapeutic cancer vaccine neoantigen peptide vaccine cancer vaccine Hayleigh Kahn VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6327 6327 Jie Zheng NCT: https://clinicaltrials.gov/study/NCT05098210 A cancer vaccine consisting of patient-specific antigens, which are immunogenic and unique to the patient's tumor, with potential immunomodulating and antineoplastic activities. The neoantigen peptide vaccine, the peptides stimulate the host immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. Personalized neo-antigen peptide vaccine is a product combines multiple patient specific neo-antigens. Given personalized neo-antigen peptide vaccine together with Th1 polarizing adjuvant poly ICLC may induce a polyclonal, poly-epitope, cytolytic T cell immunity against the patient's tumor. Patients also receive nivolumab. NCI: https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C165508