has function has role immunizes against disease immunizes recipient cancer Homo sapiens vaccine in research role subunit vaccine therapeutic vaccine function subunit vaccine role therapeutic cancer vaccine personal neoantigen cancer vaccine cancer vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6387 Hayleigh Kahn A cancer vaccine designed to target the unique immunogenic mutations arising in each patient's tumor. Peptide binding to MHC is a critical gateway to both the initiation of a T-cell immune response by the antigen presenting cell (APC), and to the detection and elimination of tumor cells presenting the particular peptide by the stimulated cytotoxic T lymphocyte (CTL). The attraction of neoantigens as cancer targets for the immune system results from the structural and geographical features of the mutation. Neoantigen peptides are only found in tumor cells, so CTLs should show exquisite specificity, reducing the opportunity for autoimmune disease. 6387 PMID:25101225 Jie Zheng