has function has role vaccinated in route immunizes against disease immunizes recipient breast cancer Homo sapiens therapeutic vaccine function DNA vaccine role vaccine in clinical trial role intradermal route breast cancer vaccine therapeutic cancer vaccine DNA cancer vaccine pUMVC3-IGFBP2-HER2-IGF1R plasmid DNA vaccine 6346 3480 Gene name: IGF1R NCI: https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C127910 Jie Zheng Hayleigh Kahn VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6346 NCT: https://clinicaltrials.gov/study/NCT02780401 3485 Gene name: HER2 2064 A cancer vaccine containing the mammalian expression vector pUMVC3 encoding epitopes derived from three tumor-associated antigens (TAAs): human insulin-like growth factor-binding protein 2 (IGFBP2), human epidermal growth factor receptor 2 (HER2; ERBB2) and insulin-like growth factor 1 receptor (IGF1R), with potential immunostimulating and antineoplastic activities. The vaccine This activates the immune system to mount a combined response from specific T helper type 1 (Th1) cells, memory T-cells and cytotoxic T-lymphocytes (CTL) against IGFBP2-, HER2-, and IGF1R-expressing tumor cells. This vaccine may prevent cancer from coming back in patients with non-metastatic, node positive, human epidermal growth factor receptor (HER)2 negative breast cancer in which all signs and symptoms have disappeared. Vaccines made from deoxyribonucleic acid (DNA) may help the body build an effective immune response to kill tumor cells. It is given in combination with sargramostim. Gene name: IGFBP2 cancer vaccine