has function has role immunizes against disease immunizes recipient cancer Homo sapiens subunit vaccine therapeutic vaccine function subunit vaccine role vaccine in clinical trial role therapeutic cancer vaccine secPD-L1 vaccine A cancer vaccine made with secPD-L1, a splice variant of PD-L1 (programmed death ligand-1, an immune checkpoint pathway) that does not splice into the transmembrane domain, but instead produces a secreted form of PD-L1 that has a unique 18 amino acid tail containing a cysteine that allows it to homodimerize and more effectively inhibit lymphocyte function than monomeric soluble PD-L1. Recombinant secPD-L1 can dimerize and inhibit T-cell proliferation and IFN-gamma production in vitro. SecPD-L1 may function as a paracrine negative immune regulator within the tumor, since secPD-L1 does not require a cell-to-cell interaction to mediate its inhibitory effect. This could lead to improved survival for patients with numerous types of cancers, including lung cancer, melanoma, renal cell carcinoma, and Hodgkin lymphoma. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=6376 cancer vaccine Gene name: PD-L1 6376 PMID:30564891 Jie Zheng Hayleigh Kahn 29126