has role immunizes against disease immunizes recipient immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus Bos taurus vaccine in research role live attenuated Brucella abortus vaccine cattle vaccine live attenuated Brucella abortus strain 2308 znuA purE double mutant vaccine 2026-10-25T08:06:33Z PMID:19914192 VaxAgent VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12138 vaccine Jie Zheng 12138 Live attenuated Brucella abortus vaccine using live attenuated double mutant strain of Brucella abortus 2308 with deletions in znua and pure genes. Two doses of the double mutant conferred 0.79 log protection, similar to S19 vaccine. Double mutant was less capable of surviving in macrophages and caused significantly less inflammation in spleens of infected mice compared to wild-type strain. live attenuated vaccine role