has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus vaccine in research role live attenuated Brucella abortus vaccine live attenuated Brucella abortus 2308 delta pgk vaccine 2026-10-25T08:06:33Z VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12141 Jie Zheng Live attenuated Brucella abortus vaccine using live attenuated Brucella abortus delta pgk mutant strain. Delta pgk mutant strain exhibited extreme attenuation and induced protective immunity superior to that conferred by commercial strain 19 or RB51 vaccines in both immunocompetent and immunocompromised mice. Mutant strain showed altered intracellular trafficking with retention in late endosomal/lysosomal compartments (lamp1 positive), indicating impaired intracellular survival. PMID:20194591 12141 VaxAgent vaccine live attenuated vaccine role