has role immunizes against disease immunizes recipient immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus Homo sapiens vaccine in research role live attenuated Brucella abortus vaccine live attenuated Brucella abortus 2308 delta BAB1_0542 vaccine 2026-10-25T08:06:33Z PMID:23507429 12194 VaxAgent Jie Zheng VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12194 vaccine Live attenuated Brucella abortus vaccine using mutant strain s2308δatp with ABC transporter atpase gene deletion, exhibiting rough phenotype and altered growth rate compared to wild type. Mutant strain s2308δatp showed attenuated virulence in vitro and in vivo. Expression levels of MHC i, MHC ii, and co-stimulatory molecules were investigated in mice following infection with s2308δatp and wild type s2308, indicating immune activation differences. live attenuated vaccine role