<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/VO?iri=http://purl.obolibrary.org/obo/VO_0009323"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:dcterms="http://purl.org/dc/terms/"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/VO_0001818"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.org/dc/terms/date"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001011 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0001011">
        <rdfs:label>immunizes against disease</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/VO_0003355 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0003355">
        <rdfs:label>immunizes against pathogen</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/VO_0003390 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0003390">
        <rdfs:label>test in lab animal model</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/DOID_11077 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_11077">
        <rdfs:label xml:lang="en">brucellosis</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_10090 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_10090">
        <rdfs:label>Mus musculus</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_235 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_235">
        <rdfs:label>Brucella abortus</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000208 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000208">
        <rdfs:label>vaccine in research role</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000636 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000636">
        <rdfs:label>recombinant vector vaccine role</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000957 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000957">
        <rdfs:label>Brucella abortus recombinant vector vaccine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001134 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0001134">
        <rdfs:label>live attenuated Brucella abortus vaccine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0009323 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0009323">
        <rdfs:label>live attenuated Brucella abortus delta pgm E. coli O157:H7 recombinant vaccine</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000957"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0001134"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0001011"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DOID_11077"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000636"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003390"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000208"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_235"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0010038"/>
            </Restriction>
        </rdfs:subClassOf>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2026-10-25T08:06:33Z</dcterms:date>
        <oboInOwl:hasDbXref>VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12241</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>Live attenuated Brucella abortus vaccine using A 66kda chimeric antigen composed of espa, intimin, tir, and H7 flagellin (eith7) from STEC was constructed and expressed in Brucella abortus δpgm vaccine strain (babδpgm). Mice immunized with babδpgm(eith7) cleared intestinal e. Coli o157:h7 infection three times faster (4 days) than mice immunized with babδpgm carrier strain (12 days). Induction of anti-eith7 iga antibodies and protective.</ns3:IAO_0000115>
        <ns3:IAO_0000117> Jie Zheng</ns3:IAO_0000117>
        <oboInOwl:inSubset>vaccine</oboInOwl:inSubset>
        <ns3:IAO_0000117>VaxAgent </ns3:IAO_0000117>
        <ns3:VO_0001818>12241</ns3:VO_0001818>
        <ns3:IAO_0000119>PMID:25820069</ns3:IAO_0000119>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0010038 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0010038">
        <rdfs:label>live attenuated vaccine role</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



