has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus vaccine in research role live attenuated Brucella abortus vaccine live attenuated Brucella abortus wbdR-inserted vaccine 2026-10-25T08:06:33Z PMID:29887851 VaxAgent 12319 Jie Zheng vaccine VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12319 Live attenuated Brucella abortus vaccine using live Brucella abortus constructs with chromosomal insertion of wbdr gene, some with deletion of the native wbkc formyltransferase gene, producing modified lipopolysaccharide structures. Wbdr constructs produced chronic infections in mice and elicited antibody responses distinguishable from wild-type strains, indicating potential for vaccine development. Modified vaccines triggered antibodies to new immunogenic epitopes lacking the a, m, and C epitopes of wild-type strains, allowing differentiation in serological tests. live attenuated vaccine role