has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella melitensis vaccine in research role live attenuated Brucella melitensis vaccine live attenuated Brucella melitensis vaccine with wbdR acetyl-transferase gene insertion 2026-10-25T08:06:33Z PMID:29887851 VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12320 Jie Zheng vaccine Live attenuated Brucella melitensis vaccine using live Brucella abortus constructs with chromosomal insertion of wbdr gene, some with deletion of the native wbkc formyltransferase gene, producing modified lipopolysaccharide structures. Wbdr constructs produced chronic infections in mice and elicited antibody responses distinguishable from wild-type strains, indicating potential for vaccine development. Modified vaccines triggered antibodies to new immunogenic epitopes lacking the a, m, and C epitopes of wild-type strains, allowing differentiation in serological tests. VaxAgent 12320 live attenuated vaccine role