has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus vaccine in research role live attenuated Brucella abortus vaccine live attenuated Brucella abortus strain 19 wbkA gene deletion vaccine 2026-10-25T08:06:33Z vaccine VaxAgent 12372 PMID:32195284 Jie Zheng Live attenuated Brucella abortus vaccine using A wbka gene knockout mutant of Brucella abortus strain 19 was constructed to produce a strain deficient in LPS o-chain structure. Wbka mutant induced a splenocyte proliferative response in mice comparable or superior to parental S19 and RB51 strains, indicating immunogenicity. Mutant strain did not induce igm antibody response detectable by elisa, suggesting reduced interference in serological differentiation between vaccinated and infected animals. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12372 live attenuated vaccine role