has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella melitensis vaccine in research role live attenuated Brucella melitensis vaccine live attenuated Brucella melitensis 16M delta wzm vaccine 2026-10-25T08:06:33Z VaxAgent Live attenuated Brucella melitensis vaccine using live attenuated Brucella melitensis 16M strain with an in-frame deletion of the wzm gene, administered by subcutaneous or conjunctival routes. In mice, 16mδwzm prevented placental and fetal infections and protected against Brucella melitensis and Brucella ovis infections. Efficacy in the natural host (sheep) remains to be confirmed. Vaccination induced transient rose bengal serological reactions, stronger and earlier in pregnant ewes. VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12444 Jie Zheng PMID:36653223 vaccine 12444 live attenuated vaccine role