has role immunizes against disease immunizes recipient immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella abortus Sus scrofa vaccine in research role recombinant vector vaccine role Brucella abortus recombinant vector vaccine live attenuated Brucella abortus vaccine pig vaccine live attenuated Brucella abortus multi-epitope outer membrane protein Lactococcus lactis vector vaccine 2026-10-25T08:06:33Z Jie Zheng Brucella abortus multi-epitope OMPs vaccine based on Lactococcus lactis live bacterial vectors Live attenuated Brucella abortus vaccine using oral administration of genetically modified lactococcus lactis expressing a 39 kda multi-epitope omps protein encoded by a plasmid constructed via reverse vaccinology. Vaccinated mice showed reduced spleen morphological damage, less inflammation, lymphocyte infiltration, and lesions compared to controls. Vaccination induced significant igg1 antibodies specific to omps, increased interferon lambda (ifn-λ) and tumor necrosis factor alpha (tnf-α) levels, and enhanced transcription of interleukin 4 (il-4) and interleukin 10 (il-10). VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12471 12471 VaxAgent vaccine PMID:38703567 live attenuated vaccine role