has role immunizes against disease immunizes against pathogen test in lab animal model brucellosis Mus musculus Brucella melitensis vaccine in research role live attenuated Brucella melitensis vaccine live attenuated Brucella melitensis vtlR mutant vaccine 2026-10-25T08:06:33Z VaxAgent VIOLIN: https://violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=12512 vaccine Jie Zheng 12512 PMID:41204344 Live attenuated Brucella melitensis vaccine using live attenuated vtlr deletion mutant strain of Brucella melitensis M5. Vtlr mutant strain showed reduced intracellular survival and triggered reactive oxygen species production. Mutant strain induced protective immunity in mice, associated with increased reactive oxygen species production in macrophages. live attenuated vaccine role