has role protective antigen role protective antigen Classical swine fever virus protein E2 from Classical swine fever virus Oliver He Protegen ID: 442; NCBI Gene GI: 920146; NCBI Protein GI: 12657942; NCBI Protein Accession: NP_075354; NCBITaxon: 11096 Pigs were subjected to challenge infection with a dose of 1x10(5)TCID(50) (50% tissue culture infective dose) virulent CSFV strain. At 1 week post challenge infection, all of the yE2-immunized pigs were alive and without symptoms or signs of CSF. The yeast-expressed E2 protein retains correct immunogenicity and is able to induce a protective immune response against CSFV infection [PubMed: 19625145]. In a seperate study, swine vaccinated with VVR expressing E0 and/or E2 resisted a lethal challenge infection with CSFV. Glycoprotein E0 represents a second determinant for the induction of protective immunity against classical swine fever [PubMed: 7666549]. protein Allen Xiang