<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/VO?iri=http://purl.obolibrary.org/obo/VO_0011200"?>
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     xmlns:owl="http://www.w3.org/2002/07/owl#"
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    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    


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    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002162 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002162">
        <rdfs:label>in taxon</rdfs:label>
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    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
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    <!-- http://purl.obolibrary.org/obo/OPL_0000332 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OPL_0000332">
        <rdfs:label>Neospora caninum tachyzoite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0000457 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000457">
        <rdfs:label>protective antigen role</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001232 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0001232">
        <rdfs:label>protective antigen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0010828 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0010828">
        <rdfs:label>Neospora caninum protein</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0011200 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0011200">
        <rdfs:label>NcMIC1</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0001232"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0010828"/>
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            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
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                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OPL_0000332"/>
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        <rdfs:comment>Study assessed the potential protectivity of NcMIC1-based vaccination against experimental N. caninum infection in mice.  Quantitative real-time PCR revealed that the infection intensity was significantly reduced in the group vaccinated with recNcMIC1 antigen.  Serological analysis showed that only recNcMIC1-immunized animals generated detectable antibody levels recognizing native NcMIC1. Thus, of all protocols applied, only recNcMIC1 vaccination appears to be suited to reduce cerebral infection in mice challenged with N. caninum tachyzoites [PubMed: 16108562].</rdfs:comment>
        <ns3:IAO_0000117>Allen Xiang</ns3:IAO_0000117>
        <rdfs:seeAlso>Protegen ID: 616; NCBI Protein GI: 17226315; NCBITaxon: 29176</rdfs:seeAlso>
        <ns3:IAO_0000117>Oliver He</ns3:IAO_0000117>
        <oboInOwl:inSubset>protein</oboInOwl:inSubset>
    </Class>
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