<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/VO?iri=http://purl.obolibrary.org/obo/VO_0011308"?>
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     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
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     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    


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    <!-- 
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    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
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    //
    // Classes
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    <!-- http://purl.obolibrary.org/obo/VO_0000457 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0000457">
        <rdfs:label>protective antigen role</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0001232 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0001232">
        <rdfs:label>protective antigen</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0010842 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0010842">
        <rdfs:label>Cryptosporidium parvum protein</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/VO_0011308 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/VO_0011308">
        <rdfs:label>Cp23 from Crptosporidium parvum</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0001232"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0010842"/>
        <rdfs:subClassOf>
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                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/VO_0000457"/>
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        </rdfs:subClassOf>
        <rdfs:seeAlso>Protegen ID: 776; NCBI Protein GI: 88659549; NCBITaxon: 5807</rdfs:seeAlso>
        <rdfs:comment>In this study, Cp23 antigen was investigated as a vaccine candidate using the DNA vaccine model in adult interleukin-12 (IL-12) knockout (KO) mice, which are susceptible to C. parvum infection.  Cp23-DNA vaccination induced a 50-60% reduction in oocysts shedding, indicating a partial protection against C. parvum infection in IL-12 KO mice [PubMed: 17487508].</rdfs:comment>
        <ns3:IAO_0000117>Oliver He</ns3:IAO_0000117>
        <oboInOwl:inSubset>protein</oboInOwl:inSubset>
        <ns3:IAO_0000117>Anthony Huffman</ns3:IAO_0000117>
        <ns3:IAO_0000115>A Cp23 protein that is part of Crptosporidium parvum</ns3:IAO_0000115>
        <ns3:IAO_0000117>Allen Xiang</ns3:IAO_0000117>
    </Class>
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