has role protective antigen role protective antigen Treponema pallidum protein TmpB Oliver He Allen Xiang protein Protegen ID: 857; NCBI Gene GI: 2611387; NCBI Protein GI: 15639756; NCBI Protein Accession: NP_219206; NCBITaxon: 243276 Treponema pallidum-susceptible guinea pigs of strain C4D were immunized with recombinant T. pallidum antigen TmpB. Guinea pigs receiving TmpB antigen demonstrated protection expressed by the development of significantly (P less than 0.01) smaller, atypical lesions of significantly (P less than 0.01) shorter duration and devoid of or containing fewer T. pallidum organisms than lesions in the remaining immunized and control animals [PubMed: 1937794].