develops from ends during starts during neural crest nervous system death enteric nervous system UBERON:0002005 The mesh-like system of enteric neurons that innervate the gastrointestinal tract, with neurons embedded in the lining of the gastrointestinal system, beginning at the esophagus and extending down to the cloaca. The ENS can and does operate independently of the brain and the spinal cord. intrinsic nervous system ENS xenopus_anatomy XAO:0005195 NF stage 15