toxic substance alloxan 2,4,5,6-pyrimidinetetrone 2012-10-16T04:29:35Z 5-Oxobarbituric acid A condition in which the main influencing factor is alloxan, an oxygenated pyrimidine derivative which is toxic to the pancreatic insulin-producing beta cells of the islets of Langerhans in rodents and other animals and can therefore be used for modeling type 1 diabetes mellitus through destruction of the beta cells. XCO:0000242 alloxane experimental_condition_ontology jsmith mesoxalylurea pubchem.compound:5781 diabetes-inducing chemical