inhibitor guanethidine 2013-06-21T18:45:16Z An antihypertensive agent that acts by selectively inhibiting transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It does not appear to act at the level of the adrenergic receptors. CHEBI:5557 MESH:D006145 XCO:0000310 experimental_condition_ontology jsmith