antineoplastic agent clodronic acid (dichloromethanediyl)bis(phosphonic acid) 2019-12-10T17:07:59Z An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. XCO:0000648 clodronate experimental_condition_ontology slaulede