complex ion antineoplastic agent spiroplatin 2020-10-20T14:53:27Z A condition in which the main influencing factor is spiroplatin, a metal drug and analog of the second generation for cisplatin, developed for the treatment of cancer. Spiroplatin induces DNA cross-linking, thereby inhibiting DNA replication and the synthesis of RNA and protein. Initial clinical trials of spiroplatin showed that it could cause less nausea and vomiting than cisplatin, but development was discontinued due to weak anti-tumor effects and toxicity at high dosages. MESH:C040757 NSC-311056 TNO-6 XCO:0000778 aqua(1,1-bis(aminomethyl)cyclohexane)sulfatoplatinum (II) experimental_condition_ontology slaulede