buffer solution histidine-tryptophan-ketoglutarate solution 2024-12-09T16:25:11Z Custodiol HTK HTK Histidine-tryptophan-ketoglutarate PMID:36982476 This is any condition in which the main influencing factor is histidine-tryptophan-ketoglutarate (HTK) solution, a cardioplegic solution used in open heart surgery that is increasingly being used as a preservation solution for kidneys. in HTK tryptophan serves as a membrane stabilizer and antioxidant, ketoglutarate acts as a substrate for anaerobic metabolism during preservation and histidine serves as a pH-buffering component. XCO:0001480 experimental_condition_ontology slaulederkind