neoplasm-inducing chemical protein kinase inhibitor TRULI 2025-05-29T14:35:10Z CAS:1424635-83-5 GEO:GSE249368 LATS Inhibitor 1 Lats-IN-1 N-[(2E)-3-Benzyl-1,3-thiazol-2(3H)-ylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide PMID:39938686 This is any condition in which the main influencing factor is TRULI, a potent and ATP-competitive inhibitor of Lats1 (large tumor suppressor kinase 1) and Lats2 (large tumor suppressor kinase 2) kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues by inhibiting phosphorylation of YES1-associated transcriptional regulator (YAP1). XCO:0001629 experimental_condition_ontology slaulederkind