ester enzyme inhibitor antilipemic agent simvastatin 2025-10-23T11:46:48Z CHEBI:9150 CID:54454 GEO:GSE296883 PMID:40502156 This is any condition in which the main influencing factor is simvastatin, a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. XCO:0001737 Zocor experimental_condition_ontology slaulederkind