part_of part of part of MAPK cascade protein serine/threonine kinase activity MAP kinase activity mitogen activated kinase activity SAP kinase activity Reactome:R-HSA-73722 MAP kinase 1 activity mitogen-activated protein kinase activity MBP kinase II activity MBP kinase I activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. Reactome:R-HSA-9825759 EC:2.7.11.24 SAPK stress-activated protein kinase activity stress-activated kinase activity ERK GO:0016908 molecular_function GO:0016909 myelin basic protein kinase activity ERK1 extracellular signal-regulated kinase activity GO:0004707 ATP:protein phosphotransferase (MAPKK-activated) activity Reactome:R-HSA-198733 Reactome:R-HSA-9626832 MAPK Reactome:R-HSA-445079 Reactome:R-HSA-5654560 ERK2 Reactome:R-HSA-5654565 Reactome:R-HSA-5654562 Reactome:R-HSA-111898 MAP kinase 2 activity KEGG_REACTION:R00162 MetaCyc:2.7.11.24-RXN GO:0008339 GO:0008338 Reactome:R-HSA-5654566