phosphatidylinositol 3-kinase/protein kinase B signal transduction https://github.com/geneontology/go-ontology/issues/25656 AKT signal transduction protein kinase B signal transduction phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction AKT signaling PI3K/Akt signal transduction PI3K-PKB/Akt pathway GO:0043491 Reactome:R-HSA-198693 PKB signaling cascade AKT signaling cascade PKB signal transduction AKT signalling cascade An intracellular signaling cassette that starts with phosphatidylinositol 3-kinase (PI3K) activation, production of phosphatidylinositol 3-phosphate (PI3P), activation of PDK1, which recruits and ending with the activation of protein kinase B (PKB, also known as Akt). PI3K is activated by cell surface receptors. Note that PTEN is an inhibitor of the pathway. biological_process protein kinase B signalling cascade PKB signalling cascade PKB signaling protein kinase B signaling cascade PI3K/PKB signal transduction protein kinase B signaling Reactome:R-HSA-198323 Reactome:R-HSA-198203 intracellular signaling cassette