MAPK cascade
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
MAPK signalling
MAPK signaling
Wikipedia:MAPK_cascade
MAPK signal transduction
ERK/MAPK cascade
MAP kinase cascade
MAPKKK cascade during sporulation
GO:0007255
biological_process
MAP kinase kinase kinase cascade
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
MAPKKK cascade
GO:0000165
mitogen-activated protein kinase cascade
Wikipedia:Mitogen-activated_protein_kinase
intracellular signal transduction