has role is protonated form of has functional parent hydroxy polyunsaturated fatty acid leukotriene B4 A leukotriene composed of (6<i>Z</i>,8<i>E</i>,10<i>E</i>,14<i>Z</i>)-icosatetraenoic acid having (5<i>S</i>)- and (12<i>R</i>)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. long-chain fatty acid leukotriene dihydroxy monocarboxylic acid icosa-6,8,10,14-tetraenoic acid vasoconstrictor agent leukotriene B4(1-) mouse metabolite plant metabolite human metabolite