has role 3,3',5-triiodo-L-thyronine An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. iodophenol iodothyronine 2-halophenol 3,3',5-triiodo-L-thyronine zwitterion 3,3',5-triiodo-L-thyroninate thyroid hormone mouse metabolite human metabolite