immortal cell line cell hybridoma cell line cell an immortal cell line cell that is established by fusing a specific antibody-producing B cell with a myeloma (B cell cancer) cell that is selected for its ability to produce a monoclonal antibody. The production of monoclonal antibodies using the hybridoma technology was invented by Cesar Milstein and Georges J. F. Köhler in 1975. They shared the Nobel Prize of 1984 for Medicine and Physiology with Niels Kaj Jerne, who made other contributions to immunology. Yongqun He WEB: http://en.wikipedia.org/wiki/Hybridoma_technology