part_of part of part of capable of capable of material entity material entity cell type cell keratinizing barrier epithelial cell keratinocyte Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. FMA:62879 BTO:0000667 CALOHA:TS-0500 EFO_URI: http://www.ebi.ac.uk/efo/EFO_0000560 malpighian cell Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. James Malone CL:0002185 CL:0000312 URI: http://www.ebi.ac.uk/cellline#keratinocyte BTO:0000667 An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. cell keratinized cell of epidermis malpighian cell An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. epidermal cell antimicrobial peptide production antimicrobial peptide secretion positive regulation of neutrophil chemotaxis skin epidermis