has part has part has_part participates in participates_in participates in develops_from develops from common lymphoid progenitor pro-B cell progenitor B lymphocyte progenitor B-cell BTO:0003104 progenitor B-lymphocyte pre-B cell (Philadelphia nomenclature) progenitor B cell pro-B-lymphocyte cell Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. pro-B-cell A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. pre-pro B cell pro-B lymphocyte lymphoid lineage restricted progenitor cell immunoglobulin V(D)J recombination paired box protein PAX-5 DNA nucleotidylexotransferase