central nervous system disease amyotrophic lateral sclerosis ORDO:803 ICD9CM:335.20 ICD10CM:G12.21 UMLS_CUI:C0002736 ALS EFO:0000253 MESH:D000690 MESH:D000690 DOID:332 NCI:C34373 A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. Lou Gehrig's disease SNOMEDCT_US_2021_09_01:86044005 disease_ontology OMIM:PS105400 GARD:5786 KEGG:05014 motor neuron disease, bulbar