macromolecule metabolic process cellular metabolic process cellular macromolecule metabolic process GO:0034960 cellular macromolecule metabolism GO:0044260 biological_process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. cellular biopolymer metabolic process