part_of part of part of has part has part has_part overlaps overlaps only in taxon only_in_taxon develops_from develops from contributes to morphology of produces produces site_of hepatic immune response glycogen biosynthetic process glycogen catabolic process Vertebrata <Metazoa> Vertebrata <vertebrates> bile liver Leber:Schaf.jpg https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg EV:0100089 Organ which secretes bile and participates in formation of certain blood proteins.[AAO] BTO:0000759 MAT:0000097 TAO:0000123 EHDAA2:0000997 secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. EFO:0000887 An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. galen:Liver hepatic GAID:288 MESH:D008099 The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates. Wikipedia:Liver VHOG:0000257 MA:0000358 NCIT:C12392 EHDAA:2197 MIAA:0000097 uberon All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG] FMA:7197 AAO:0010111 SCTID:181268008 An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003). CALOHA:TS-0564 Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function. iecur EMAPA:16846 ZFA:0000123 OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO] XAO:0000133 UBERON:0002107 jecur UMLS:C0023884 exocrine gland immune system hepatobiliary system endoderm-derived structure septum transversum liver lobule abdomen element digestive system gland liver bud