neuroectodermal tumor Ewings sarcoma A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. (From Dorland, 27th ed; Stedman, 25th ed) Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms. Ewing's Family of Tumors GeneRIF:15748890 Ewing sarcoma GeneRIF:15077162 NCIt:C4817 GeneRIF:15310753 ES GeneRIF:15282325 Tomasz Adamusiak DOID:3369 Ewing's tumour GeneRIF:11956622 GeneRIF:12700668 Ewing's Family of Tumours GeneRIF:12557222 GeneRIF:15273724 GeneRIF:11992404 GeneRIF:12447693 GeneRIF:12172985 GeneRIF:12054564 Ewing's sarcoma GeneRIF:15044653 GeneRIF:14977835 Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor MSH:D012512 A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms. -- 2004 GeneRIF:15328192 GeneRIF:11313995 Ewing's sarcoma (morphologic abnormality) Tumors of the Ewing's Family Ewing Tumor GeneRIF:12527902 NCIt:C27291 URI: http://www.ebi.ac.uk/cellline#Ewing_sarcoma GeneRIF:15919668 A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms. James Malone GeneRIF:15581626 GeneRIF:14528100 SNOMEDCT:76909002 Ewing Family of Tumors Ewings Tumor osteosarcoma