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    <!-- http://purl.obolibrary.org/obo/DOID_2583 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_2583">
        <rdfs:label>agammaglobulinemia</rdfs:label>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000367 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000367">
        <rdfs:label>common variable immunodeficiency</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_2583"/>
        <rdfs:comment>Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.</rdfs:comment>
        <ns2:IAO_0000118>CVAG</ns2:IAO_0000118>
        <ns2:IAO_0000118>acquired hypogammaglobulinemia</ns2:IAO_0000118>
        <ns2:IAO_0000118>CVI - Common variable immunodeficiency</ns2:IAO_0000118>
        <ns2:IAO_0000118>Sporadic hypogammaglobulinemia</ns2:IAO_0000118>
        <ns2:IAO_0000118>Late onset immunoglobulin deficiency</ns2:IAO_0000118>
        <rdfs:seeAlso>URI: http://www.ebi.ac.uk/cellline#common_variable_immunodeficiency</rdfs:seeAlso>
        <ns2:IAO_0000119>NCIt:C26725</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12100033</ns2:IAO_0000119>
        <ns2:IAO_0000118>Acquired Agammaglobulinemia</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:16007086</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15507387</ns2:IAO_0000119>
        <ns2:IAO_0000119>SNOMEDCT:23238000</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:16007087</ns2:IAO_0000119>
        <ns2:IAO_0000118>CVID</ns2:IAO_0000118>
        <ns2:IAO_0000118>Common variable hypogammaglobulinaemia</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:12759461</ns2:IAO_0000119>
        <ns2:IAO_0000119>ICD9:279.06</ns2:IAO_0000119>
        <ns2:IAO_0000118>Common variable agammaglobulinemia</ns2:IAO_0000118>
        <ns2:IAO_0000118>Common variable hypogammaglobulinemia</ns2:IAO_0000118>
        <rdfs:comment>A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.</rdfs:comment>
        <ns2:IAO_0000119>DOID:12177</ns2:IAO_0000119>
        <ns2:IAO_0000118>COMMON VARIABL IMMUNODEF</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15598813</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15817684</ns2:IAO_0000119>
        <ns2:IAO_0000118>Acquired hypogammaglobulinaemia</ns2:IAO_0000118>
        <ns2:IAO_0000117>James Malone</ns2:IAO_0000117>
        <rdfs:comment>A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).</rdfs:comment>
        <ns2:IAO_0000118>Common variable agammaglobulinaemia</ns2:IAO_0000118>
        <ns2:IAO_0000119>MSH:D017074</ns2:IAO_0000119>
        <ns2:IAO_0000118>Immunodeficiencies, Common Variable</ns2:IAO_0000118>
        <ns2:IAO_0000118>Common variable agammaglobulinemia (disorder)</ns2:IAO_0000118>
        <ns2:IAO_0000118>COMMON VARIABLE IMMUNODEFIC</ns2:IAO_0000118>
        <ns2:IAO_0000118>CVID - Common variable immunodeficiency</ns2:IAO_0000118>
        <ns2:IAO_0000118>common variable immunodeficiency</ns2:IAO_0000118>
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