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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    


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    <!-- 
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    <!-- http://purl.obolibrary.org/obo/DOID_183 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_183">
        <rdfs:label>bone tissue neoplasm</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DOID_3349 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_3349">
        <rdfs:label>osteogenic neoplasm</rdfs:label>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000637 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000637">
        <rdfs:label>osteosarcoma</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_183"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_3349"/>
        <ns2:IAO_0000119>GeneRIF:16328004</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12237108</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15488761</ns2:IAO_0000119>
        <rdfs:seeAlso>URI: http://www.ebi.ac.uk/cellline#osteosarcoma</rdfs:seeAlso>
        <ns2:IAO_0000119>GeneRIF:15476586</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14679136</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:16087680</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14524531</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:11927012</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:11776394</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15310147</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:13678785</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12209731</ns2:IAO_0000119>
        <ns2:IAO_0000119>SNOMEDCT:21708004</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12054567</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15210853</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteochondrosarcoma</ns2:IAO_0000118>
        <rdfs:comment>A malignant mesenchymal tumor arising from the bone.</rdfs:comment>
        <ns2:IAO_0000119>GeneRIF:15087387</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12479099</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12154052</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma, NOS</ns2:IAO_0000118>
        <ns2:IAO_0000118>Osteogenic sarcoma, NOS</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15580288</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma of bone</ns2:IAO_0000118>
        <ns2:IAO_0000118>Sarcoma of Bone</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15583032</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12393937</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12788094</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteogenic Sarcomas</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15221963</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15900593</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15870699</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:11606061</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15145525</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcomas</ns2:IAO_0000118>
        <rdfs:comment>A usually aggressive malignant bone-forming mesenchymal tumor, predominantly affecting adolescents and young adults.  It usually involves bones and less frequently extraosseous sites.  It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus).  Pain with or without a palpable mass is the most frequent clinical symptom.  It may spread to other anatomic sites, particularly the lungs.</rdfs:comment>
        <ns2:IAO_0000119>GeneRIF:15609301</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15662138</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma, no ICD-O subtype</ns2:IAO_0000118>
        <ns2:IAO_0000118>[M]Osteosarcoma NOS</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:14704791</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma - disorder</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:16010425</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15922739</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12544770</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14598886</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15701832</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma, no ICD-O subtype (morphologic abnormality)</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15448009</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15814634</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteoblastic osteosarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000118>Skeletal sarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15796961</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteosarcoma of bone (disorder)</ns2:IAO_0000118>
        <ns2:IAO_0000119>NCIt:C9145</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12009018</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14645574</ns2:IAO_0000119>
        <ns2:IAO_0000119>DOID:3347</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14719070</ns2:IAO_0000119>
        <ns2:IAO_0000118>Bone Sarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:12972634</ns2:IAO_0000119>
        <ns2:IAO_0000118>Sarcoma of the Bone</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15668906</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15719069</ns2:IAO_0000119>
        <ns2:IAO_0000117>James Malone</ns2:IAO_0000117>
        <ns2:IAO_0000119>GeneRIF:12792742</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:16035619</ns2:IAO_0000119>
        <ns2:IAO_0000119>MSH:D012516</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:12663494</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:16157226</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14710359</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14584080</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:11746983</ns2:IAO_0000119>
        <ns2:IAO_0000118>osteoid sarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:11943335</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15026342</ns2:IAO_0000119>
        <rdfs:comment>A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)</rdfs:comment>
        <ns2:IAO_0000119>GeneRIF:12376862</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:11920494</ns2:IAO_0000119>
        <ns2:IAO_0000118>Sarcoma, Osteogenic</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:15469899</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:15201972</ns2:IAO_0000119>
        <ns2:IAO_0000119>NCIt:C9312</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osseous Sarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>SNOMEDCT:307576001</ns2:IAO_0000119>
        <ns2:IAO_0000119>GeneRIF:14528100</ns2:IAO_0000119>
        <ns2:IAO_0000118>osteosarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:12660817</ns2:IAO_0000119>
        <ns2:IAO_0000118>Osteoblastic sarcoma</ns2:IAO_0000118>
        <ns2:IAO_0000119>GeneRIF:12709413</ns2:IAO_0000119>
    </Class>
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