syndrome inborn errors of metabolism progeria URI: http://www.ebi.ac.uk/cellline#progeria_syndrome An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA. Premature senility syndrome GeneRIF:12768443 A very rare genetic disorder caused by mutations in the LMNA gene. It is characterized by premature aging. Signs and symptoms include failure to thrive, limited growth, alopecia, wrinkled skin, small face, development of atherosclerosis, and heart disease. There is no cure for this condition. Individuals do not usually survive beyond their early twenties. Death usually occurs as a result of complications from atherosclerosis. GeneRIF:12714972 Hutchinson Gilford Syndrome Progeria syndrome (disorder) [Ambiguous] GeneRIF:12702809 NCIt:C34951 SNOMEDCT:238870004 Hutchinson-Gilford Progeria syndrome DOID:3911 HGPS Progeria (disorder) Hutchinson-Gilford syndrome (disorder) James Malone progeria syndrome Hutchinson-Gilford Disease GeneRIF:12735900 Progeria GeneRIF:15342704 GeneRIF:15608054 MSH:D011371