motor neuron disease movement disorder ophthalmoplegia basal ganglia disease tauopathy progressive supranuclear palsy Tomasz Adamusiak Progressive supranuclear ophthalmoplegia URI: http://www.ebi.ac.uk/cellline#supranuclear_palsy,_progressive progressive supranuclear ophthalmoplegia (disorder) DOID:678 Steele-Richardson-Olszewski Disease Ele Holloway James Malone supranuclear palsy, progressive NIFSTD:birnlex_12697 A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei (MeSH). Steele-Richardson-Olszewski Syndrome